Cell-Penetrating Antimicrobial Peptides – Prospectives for Targeting Intracellular Infections
نویسندگان
چکیده
منابع مشابه
Intracellular Targeting Mechanisms by Antimicrobial Peptides.
Antimicrobial peptides (AMPs) are expressed in various living organisms as first-line host defenses against potential harmful encounters in their surroundings. AMPs are short polycationic peptides exhibiting various antimicrobial activities. The principal antibacterial activity is attributed to the membrane-lytic mechanism which directly interferes with the integrity of the bacterial cell membr...
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There is a pressing need for novel and innovative therapeutic strategies to address infections caused by intracellular pathogens. Peptide nucleic acids (PNAs) present a novel method to target intracellular pathogens due to their unique mechanism of action and their ability to be conjugated to cell penetrating peptides (CPP) to overcome challenging delivery barriers. In this study, we targeted t...
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ژورنال
عنوان ژورنال: Pharmaceutical Research
سال: 2015
ISSN: 0724-8741,1573-904X
DOI: 10.1007/s11095-014-1550-9